| Autor: |
Grazioso, G., Moretti, L., Scapozza, L., Amici, M. De, Micheli, C. De |
| Zdroj: |
Journal of Medicinal Chemistry; August 2005, Vol. 48 Issue: 17 p5489-5494, 6p |
| Abstrakt: |
NR2 subunits of N-methyl-d-aspartic acid (NMDA) receptors are known to bind the neurotransmitter glutamate, competitive agonists, and antagonists. Since crystallographic data of these proteins are not available, we built a homology model of the ligand binding domain of the NR2A subunit. A consensus binding mode of selected AP5-like NMDA antagonists has been ascertained using molecular docking. The present 3D model gives insights for the design of new NMDA subtype selective compounds. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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