Effect of Nonselective β-Adrenoblockers on the State of Sympathoadrenal System and Ratio of Neuroactive Amino Acids in Rat Medulla Oblongata

Autor: Turovaya, A. Yu., Kiguradze, M. I., Galenko-Yaroshevskii, P. A., Kade, A. Kh., Uvarov, A. V., Tatulashvili, D. R., Sukoyan, G. V.
Zdroj: Bulletin of Experimental Biology and Medicine; May 2005, Vol. 139 Issue: 5 p569-571, 3p
Abstrakt: Abstract Experiments on rats showed that injection of propranolol into the medulla oblongata increased the contents of epinephrine, norepinephrine, dopamine, and L-DOPA by 3.76, 1.4, 2.0, and 1.7 times, respectively. These propranolol-induced changes in the levels and ratio of neuro-transmitters were not accompanied by variations in serotonin content. Propranolol had no significant effects on the content of excitatory amino acids, except marked increase in aspartate content. The level of inhibitory amino acids increased mainly due to an increase in GABA content. The balance between excitatory and inhibitory amino acids was shifted towards inhibitory compounds.
Databáze: Supplemental Index