| Autor: |
Glasky, Alvin J, Glasky, Michelle S, Ritzmann, Ronald F, Rathbone, Michel P |
| Zdroj: |
Expert Opinion on Investigational Drugs; October 1997, Vol. 6 Issue: 10 p1413-1417, 5p |
| Abstrakt: |
Preclinical and clinical evidence support the effectiveness of neurotrophins in Alzheimer's disease (AD) and neurodegenerative diseases. Delivery of neurotrophins to target sites in the brain remains a major obstacle for their use in humans. Development of orally active agents that mimic the effects of nerve growth factor and other neurotrophins provides a promising alternative therapeutic strategy. AIT-082, a purine analogue, has been shown to reverse age-induced memory deficits in mice and is a growth factor-mimetic agent. It is orally active, rapidly penetrates the blood-brain barrier and induces the production of multiple growth factors at the appropriate target site in the central nervous system (CNS). |
| Databáze: |
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