| Abstrakt: |
Endothelins have potent biological effect in vivo which may, in part, be mediated by stimulation of cyclooxygenase metabolism of arachidonic acid. We administered endothelins (ETs) intravenously to chronically instrumented awake sheep with and without pretreatment with meclofenamate (n=8). 30 μg doses of ET-1, ET-2, and ET-3 caused similar degrees of acute elevation of pulmonary artery pressure (PPA), reduction of the dynamic compliance of the lungs (Cdyn), and increases in lung lymph flow. Pretreatment with meclofenamate inhibited the rise in PPAand reduction in Cdyn, but had no effect on lung lymph flow. We conclude that the biological effects of the endothelins on PPAand Cdyn, but not lung fluid balance, are mediated in part by cyclooxygenase products of arachidonic acid metabolism. |
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