Lymphocytopénie CD4+ et agranulocytose idiopathiques chez un toxicomane infecté par le virus de l'hépatite C : évolution à 6 ans

Autor: Lamaury, I., Brouzes, F., Pelczar, S., Lacave, J., Strobel, M.
Zdroj: Medecine et Maladies Infectieuses; November 1997, Vol. 27 Issue: 11 p922-923, 2p
Abstrakt: The authors report a case of idiopathic CD4+ lymphocytopenia (nadir 110/mm3) with esophageal candidiasis and other minor recurrent mucocutaneous infections, in a 30 year old white male followed-up during six year. Despite cumulative risk factors for HIV infection (IV drug abuse, unprotected promiscuous bisexual activity) the patient's remained negative and so did HIV RNA determined by PCR. He also had prolonged, benign, and unexplained agranulocytosis, as well as hypogammaglobulinemia, low titers of C4 complement fraction, and chronic hepatitis C infection with vasculitis due to mixed (type II) cryoglobulinemia. These associated features and the six year fluctuating but rather benign course, have not been described so far in idiopathic CD4+ lymphocytopenia.
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