| Autor: |
Aulicino, Paula C., Kopka, Julieta, Mangano, Andrea M., Rocco, Carlos, Iacono, Marisa, Bologna, Rosa, Sen, Luisa |
| Zdroj: |
AIDS Research and Human Retroviruses; February 2005, Vol. 21 Issue: 2 p158-164, 7p |
| Abstrakt: |
The Argentine HIV-1 epidemic is considered to be represented mainly by subtype B and diverse B/F recombinants, with apparent absence of pure subtype F. In this study we describe three novel HIV-1 variants isolated from four infants born in different and distant provinces of Argentina. Partial analysis of different gene fragments spanning 18.5–40.8% of the HIV-1 complete genome revealed two subtype A HIV-1 strains in siblings, a B/C recombinant with a novel mosaic structure, and a putative subtype F. Characteristic patterns of genomic and amino acid sequences of the newly reported subtype F isolate suggest a closer genetic relationship to Argentine B/F recombinants than any other subtype F strain described so far, while the A and B/C subtypes found correspond to unusual genotypes in Argentina. Understanding the origin, diversity, and spread of HIV-1 strains worldwide will be necessary for the development of an effective vaccine approach. |
| Databáze: |
Supplemental Index |
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