| Autor: |
Stouthard, J.M.L., Oude Elferink, R.P.J., Sauerwein, H.P. |
| Zdroj: |
Biochemical and Biophysical Research Communications; March 1996, Vol. 220 Issue: 2 p241-245, 5p |
| Abstrakt: |
To study the effect of interleukin-6 (IL-6) on glucose transport, 2-deoxy-D-glucose (2-DOG) uptake in 3T3-L1 adipocytes after incubation with IL-6 was measured. IL-6 increased 2-DOG uptake maximally after 5 hours by 30 ± 12%, with a half-maximal effect at an IL-6 concentration of ≈ 800 U/mL. 3-O-methylglucose uptake was stimulated in a similar way, indicating that IL-6 enhanced glucose transport rather than phosphorylation. IL-6-induced glucose transport was additive to the effect of insulin. Addition of cycloheximide did not affect the stimulatory action of IL-6, although cycloheximide itself had profound effects on basal glucose transport. We conclude that IL-6 may enhance glucose uptake by increasing GLUT-1 intrinsic activity. |
| Databáze: |
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