| Autor: |
Zuev, D., Michne, J. A., Huang, H., Beno, B. R., Wu, D., Gao, Q., Torrente, J. R., Xu, C., Conway, C. M., Macor, J. E., Dubowchik, G. M. |
| Zdroj: |
Organic Letters; June 2005, Vol. 7 Issue: 12 p2465-2468, 4p |
| Abstrakt: |
A stereocontrolled racemic synthesis of conformationally restricted analogues 2a and 2b of a potent CGRP receptor antagonist 1 by novel functionalization of 2-substituted octahydropyrido[1,2-a]pyrazin-6-ones is described. The new diastereoselective LDA-promoted α-nitration of intermediate lactams established the required trans-configuration in the desired products. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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