| Autor: |
Mayer, J. P., Hsiung, H. M., Flora, D. B., Edwards, P., Smith, D. P., Zhang, X.-Y., Gadski, R. A., Heiman, M. L., Hertel, J. L., Emmerson, P. J., Husain, S., O'Brien, T. P., Kahl, S. D., Smiley, D. L., Zhang, L., DiMarchi, R. D., Yan, L. Z. |
| Zdroj: |
Journal of Medicinal Chemistry; May 2005, Vol. 48 Issue: 9 p3095-3098, 4p |
| Abstrakt: |
A series of novel, disulfide-constrained human β-melanocyte stimulating hormone (β-MSH)-derived peptides were optimized for in vitro melanocortin-4 receptor (MC-4R) binding affinity, agonist efficacy, and selectivity. The most promising of these, analogue 18, was further studied in vivo using chronic rat food intake and body weight models. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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