| Autor: |
Liu, K., Xu, L., Berger, J. P., MacNaul, K. L., Zhou, G., Doebber, T. W., Forrest, M. J., Moller, D. E., Jones, A. B. |
| Zdroj: |
Journal of Medicinal Chemistry; April 2005, Vol. 48 Issue: 7 p2262-2265, 4p |
| Abstrakt: |
A series of 2-aryloxy-2-methyl-propionic acid compounds and related analogues were designed, synthesized, and evaluated for their PPAR agonist activities. 2-[(5,7-Dipropyl-3-trifluoromethyl)-benzisoxazol-6-yloxy]-2-methylpropionic acid (4) was identified as a PPARα/γ dual agonist with relative PPARα selectivity and demonstrated potent efficacy in lowering both glucose and lipids in animal models without causing body weight gain. The PPARα activity of 4 appeared to have played a significant role in lowering glucose levels in db/db mice. |
| Databáze: |
Supplemental Index |
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