| Autor: |
Csordás, György, Santra, Manoranjan, Reed, Charles C., Eichstetter, Inge, McQuillan, David J., Gross, Danielle, Nugent, Matthew A., Hajnóczky, György, Iozzo, Renato V. |
| Zdroj: |
Journal of Biological Chemistry; October 2000, Vol. 275 Issue: 42 p32879-32887, 9p |
| Abstrakt: |
The small leucine-rich proteoglycan decorin interacts with the epidermal growth factor receptor (EGFR) and triggers a signaling cascade that leads to elevation of endogenous p21 and growth suppression. We demonstrate that decorin causes a sustained down-regulation of the EGFR. Upon stable expression of decorin, the EGFR number is reduced by ∼40%, without changes in EGFR expression. However, EGFR phosphorylation is nearly completely abolished. Concurrently, decorin attenuates the EGFR-mediated mobilization of intracellular calcium and blocks the growth of tumor xenografts by down-regulating the EGFR kinase in vivo. Thus, decorin acts as an autocrine and paracrine regulator of tumor growth and could be utilized as an effective anti-cancer agent. |
| Databáze: |
Supplemental Index |
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