The Effect of Amifostine on the in VitroCytotoxicity of Chemotherapeutic Agents in Three Epithelial Ovarian Carcinoma Cell Lines

Autor: Ng, T.Y., Ngan, Hextan Y.S., Cheng, Danny K.L., Wong, L.C.
Zdroj: Gynecologic Oncology; November 1999, Vol. 75 Issue: 2 p194-197, 4p
Abstrakt: Objectives.Amifostine protects against a spectrum of toxicities induced by chemotherapy without affecting tumor cell kill. This is supported by clinical data and in vivoanimal studies. However, there is a paucity of data on its effect on the tumor cytotoxicity of several chemotherapeutic agents used in recurrent epithelial ovarian cancer. This study compares in vitrocytotoxicity before and after addition of amifostine.
Databáze: Supplemental Index