| Autor: |
Wicks, Ian P., Lapsys, Naras M., Baker, Elizabeth, Campbell, Lynda J., Boyd, Andrew W., Sutherland, Grant R. |
| Zdroj: |
Genomics; January 1994, Vol. 19 Issue: 1 p38-41, 4p |
| Abstrakt: |
We have recently described a human receptor tyrosine kinase (hek) that is expressed by some pre-B find thymic T cell lines, but is not detectable on normal adult human tissues. Gene cloning studies established that hekis a new member of the EPH family of receptor tyrosine kinases. The expression of hekmay normally be developmentally regulated and inappropriate expression may contribute to oscogenesis. In the present study, we have used Southern blot analysis of somatic cell hybrids and fluorescence in situhybridization to localize the hekgene to human chromosome region 3p11.2. Karyotype analysis of the cell lines that overexpress hekshowed no cytogenetically visible abnormality involving the heklocus. |
| Databáze: |
Supplemental Index |
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