| Autor: |
Davis-Smyth, T, Duncan, R C, Zheng, T, Michelotti, G, Levens, D |
| Zdroj: |
Journal of Biological Chemistry; December 1996, Vol. 271 Issue: 49 p31679-87, 9p |
| Abstrakt: |
The cloning and expression of two new human cDNAs encoding proteins highly related to the far upstream element-binding protein (FBP) are described. FBP, FBP2, and FBP3 comprise a family of single-strand DNA- binding proteins that possess all of the general features of more conventional transcription factors. The FBPs each bind sequence specifically to only one strand of the far upstream element (FUSE; originally identified upstream of c-myc), and each possesses potent activation domains when fused to the GAL4 DNA-binding domain and assayed by transient transfection. Typical of transcription factors, the proteins are most highly related in their central, DNA-binding domains, but extensive homology is also shared within the tyrosine-rich, carboxyl-terminal activation domains. Comparison with GenBank sequences revealed a fourth FBP family member encoded by Caenorhabditis elegans chromosome III, illustrating the high degree of homology in this evolutionarily ancient and conserved family. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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