| Autor: |
Yada, Y., Polakowska, R.R., Okano, Y., Nozawa, Y. |
| Zdroj: |
Biochemical and Biophysical Research Communications; February 15, 1993, Vol. 190 Issue: 3 p688-694, 7p |
| Abstrakt: |
Ganglioside GQ1b was found to induce terminal differentiation in normal epidermal keratinocytes (Yada et al. (1991) Biochem. J. 279, 665-670). In GQ1b-stimulated human keratinocytes, the increase in mRNA expression of Type I TGase preceded the increases in the TGase activity. The enhancement of its mRNA expression was inhibited when protein kinase C (PKC) was suppressed by pretreatment with an inhibitor, H-7, or down-regulation by long-term preincubation with phorbol dibutyrate. These results indicate that PKC is involvedin the activation of TGase probably via gene expression of TGase mRNA in GQ1b-induced human keratinocyte differentiation. Similar results were also obtained in Ca2+-induced differentiation.Copyright 1993, 1999 Academic Press |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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