| Autor: |
Fukuzawa, A., Watanabe, T.X., Itahara, Y., Nakajima, K., Yoshizawa-Kumagaye, K., Takei, Y. |
| Zdroj: |
Biochemical and Biophysical Research Communications; May 1996, Vol. 222 Issue: 2 p323-329, 7p |
| Abstrakt: |
A new natriuretic peptide with 27 amino acid residues has been isolated from cardiac ventricles of the bullfrog,Rana catesbeiana.Since this ventricular peptide had high sequence identity to B-type (brain) natriuretic peptide (BNP), especially to chicken BNP (74%), we named it bullfrog BNP. Thus, semi-aquatic amphibians have tetrapod-type BNP, but do not seem to have fish-type ventricular natriuretic peptide (VNP) in their ventricles. Compared with other known BNPs, the C-terminus of bullfrog BNP was elongated by two amino acid residues and was not amidated. Bullfrog BNP dose-dependently decreased arterial blood pressure in the bullfrog with a potency twofold greater than that of human ANP. Bullfrog BNP also exhibited vasodepressor, natriuretic and diuretic activities in the rat, but it was 1/3, 1/7, and 1/17 as potent as human ANP in this mammalian species. |
| Databáze: |
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