| Autor: |
Jiang, H, Xie, Y, Houston, P, Stemke-Hale, K, Mortensen, U H, Rothstein, R, Kodadek, T |
| Zdroj: |
Journal of Biological Chemistry; December 1996, Vol. 271 Issue: 52 p33181-6, 6p |
| Abstrakt: |
The RAD54 and RAD51 genes are involved in genetic recombination and double-strand break repair in the yeast Saccharomyces cerevisiae. The Rad51 protein is thought to be a yeast analogue of the Eschericia coli recA gene product and catalyzes strand exchange between homologous single- and double-stranded DNAs in vitro. RAD54 exhibits homologies to several known ATPases and is a member of the SWI2/MOT1 family. We show here that the Rad54 protein interacts with the Rad51 protein in vivo and in vitro and that the NH2-terminal 115 residues of the Rad54 protein are necessary for this interaction. Combined with previously reported results, these data imply that the Rad54 protein is part of a multiprotein yeast recombination complex. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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