Cloning of a putative ligand for the T1/ST2 receptor.

Autor: Gayle, M A, Slack, J L, Bonnert, T P, Renshaw, B R, Sonoda, G, Taguchi, T, Testa, J R, Dower, S K, Sims, J E
Zdroj: Journal of Biological Chemistry; March 1996, Vol. 271 Issue: 10 p5784-9, 6p
Abstrakt: T1/ST2 is a receptor-like molecule homologous to the type I interleukin-1 receptor. Despite this sequence similarity, we have been unable to demonstrate binding of T1/ST2 to any of the three interleukin-1 species. In searching for a ligand for T1/ST2, we have cloned a cell surface protein to which it binds. This protein is unable to initiate signal transduction by the T1/ST2 receptor in several in vitro assays.
Databáze: Supplemental Index