| Autor: |
Tonin, Patricia, Ehrenborg, Ewa, Lenoir, Gilbert, Feunteun, Jean, Lynch, Henry, Morgan, Kenneth, Zazzi, Henric, Vivier, Anne, Pollak, Michael, Huynh, Hung, Luthman, Holgar, Larsson, Catharina, Narod, Steven |
| Zdroj: |
Genomics; November 1993, Vol. 18 Issue: 2 p414-417, 4p |
| Abstrakt: |
The gene for insulin-like growth factor-binding protein 4 (IGFBP4) codes for a serum protein that binds to the family of insulin-like growth factors and modulates their activity. It has been mapped by in situhybridization to chromosome region 17q12-q21.1. We have developed a CA-repeat polymorphism from a cosmid clone containing IGFBP4. By linkage analysis, IGFBP4 maps to the chromosome 17q interval THRA1-D17S579. This interval also contains the gene for hereditary breast-ovarian cancer, BRCA1. Genetic recombination between IGFBP4 and BRCA1 places IGFBP4 centromeric to the cancer susceptibility gene and effectively excludes it as a candidate gene for BRCA1. IGFBP4 is, however, one of the closest known centromeric markers for BRCA1; the estimated recombination fraction is 0.015. IGFBP4 and D17S579 together define a 2.8-cM interval that contains BRCA1. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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