| Autor: |
McCann, Ulysse G., Schiller, Henry J., Carney, David E., Gatto, Louis A., Steinberg, Jay M., Nieman, Gary F. |
| Zdroj: |
Journal of Surgical Research; August 2001, Vol. 99 Issue: 2 p335-342, 8p |
| Abstrakt: |
Background.Positive end-expiratory pressure (PEEP) reduces ventilator-induced lung injury (VILI), presumably by mechanically stabilizing alveoli and decreasing intrapulmonary shear. Although there is indirect support for this concept in the literature, direct evidence is lacking. In a surfactant depletion model of acute lung injury we observed unstable alveolar mechanics referred to as repeated alveolar collapse and expansion (RACE) as measured by changes in alveolar area from inspiration to expiration (I − EΔ). We tested the hypothesis that over a range of tidal volumes PEEP would prevent RACE by mechanically stabilizing alveoli. |
| Databáze: |
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