| Autor: |
Kulik, V P, Kavsan, V M, van Schaik, F M, Nolten, L A, Steenbergh, P H, Sussenbach, J S |
| Zdroj: |
Journal of Biological Chemistry; January 1995, Vol. 270 Issue: 3 p1068-73, 6p |
| Abstrakt: |
Hepatocyte nuclear factor 1 (HNF-1) was found to have a potent stimulatory action on the activity of the promoter of the salmon insulin-like growth factor I (IGF-I) gene in transient transfection experiments. This liver-enriched transcription factor was shown to bind to an element in the proximal region of the promoter with distinct nucleotide sequence homology to the HNF-1 consensus binding sequence. Mutating this sequence to a variant no longer capable of HNF-1 binding resulted in the loss of the stimulatory effect. Since the sequence of the HNF-1 binding site is conserved in all mammalian, avian, and amphibian species from which the IGF-I promoter sequences have been derived to date, we propose that HNF-1 may be an important regulator of IGF-I gene expression in all of these species. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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