| Autor: |
Casali, E., Gesmundo, N., Farruggia, G., Spisni, A., Masotti, L. |
| Zdroj: |
Biochemical and Biophysical Research Communications; September 1994, Vol. 203 Issue: 3 p1385-1391, 7p |
| Abstrakt: |
HSA at appropriate concentrations shows cytostatic and/or cytotoxic effects on murine Lewis carcinoma cell line C108. The cytostatic effect is mediated by an arrest in the cell cycle machinery, with accumulation of cells in G2-M. The combination of enzymatic assays, cell cycle kinetics studies and immunoprecipitation shows that HSA causes to a certainty an accumulation of cells in the M phase, while a similar effect in G2 has still to be demonstrated. It also inhibits histone H1 kinase activity up to 95% of that of mitotic cells, having as a direct or indirect target the cdc2 complex. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
