| Autor: |
Sadar, Marianne D., Westlind, Anna, Blomstrand, Fredrik, Andersson, Tommy B. |
| Zdroj: |
Biochemical and Biophysical Research Communications; December 1996, Vol. 229 Issue: 1 p231-237, 7p |
| Abstrakt: |
The induction of CYP1A1 is mediated via the aromatic hydrocarbon (Ah) receptor. Studies from our laboratory show CYP1A1 induction by picrotoxin and phenobarbital which prompted us to examine if other ligands of the γ-aminobutyric acid (GABA) receptor could also induce CYP1A1. Here we report the nuclear translocation of the Ah receptor and its DNA binding activity to radiolabeled double-stranded synthetic xenobiotic response elements (XREs) in nuclear extracts, increased accumulation of CYP1A1 mRNA, and alterations in intracellular calcium concentrations in cells exposed to GABA receptor ligands. |
| Databáze: |
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| Externí odkaz: |
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