| Autor: |
Muir, Thomas M., Hair, Jane, Inglis, Gordon C., Dow, Jocelyn W., Lindop, George B.M., Leckie, Brenda J. |
| Zdroj: |
Journal of Molecular and Cellular Cardiology; May 1993, Vol. 25 Issue: 5 p509-518, 10p |
| Abstrakt: |
We have established optimal culture conditions for growing well-differentiated atrial myocytes from newborn rats. These myocytes show the morphological features of myocytes in intact atria; including perinuclear endocrine storage granules, contractile apparatus and numerous mitochondria. The cells synthesise, store and secret immunoreactive ANP. Stored ANP is of similar molecular weight to pro-ANP (1-126); secreted ANP is the active form ANP (99-126) but processing appears to take place slowly after secretion. ANP secretion is stimulated by endothelin. Synthesis and secretion of ANP are markedly reduced by the β-adrenergic agonist isoproterenol, and by the forskolin. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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