| Autor: |
Pravtcheva, Dimitrina D., Wise, Thomas L. |
| Zdroj: |
Genomics; February 2001, Vol. 72 Issue: 1 p78-87, 10p |
| Abstrakt: |
Oligosyndactylism(Os) is a radiation-induced mouse mutation associated with recessive lethality and a dominant effect on limb and kidney development. The lethal effect of the mutation is due to a cell-autonomous block in the transition from metaphase to anaphase. We have previously characterized two transgene-induced mutations, 94-A and 94-K, which are allelic with Os.These mutations facilitated the identification of genomic segments and transcribed sequences in the affected region. One of the transcripts in this region corresponds to the mouse homolog of the anaphase-promoting complex component APC10/DOC1. The disruption of this gene can explain the mitotic arrest phenotype of all three alleles of Os. |
| Databáze: |
Supplemental Index |
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