| Autor: |
Cantore, Maurizio, Mambrini, Andrea, Fiorentini, Giammaria, Rabbi, Carla, Zamagni, Donatella, Caudana, Roberto, Pennucci, Cristina, Sanguinetti, Franco, Lombardi, Mirko, Nicoli, Nicola |
| Zdroj: |
Cancer; April 2005, Vol. 103 Issue: 7 p1402-1407, 6p |
| Abstrakt: |
BACKGROUNDPatients with unresectable biliary tract carcinomas have a very poor prognosis. To improve the efficacy and tolerance of the ECF regimen epirubicin at a dose of 50 mgm2, cisplatin at a dose of 60 mgm2, and 5fluorouracil 5FU at a dose of 200 mgm2per day by continuous infusion, the authors designed a novel approach that combined locoregional and systemic chemotherapy with the same agents at the same dosages.METHODSThirty consecutive patients with advanced or metastatic biliary tumors were treated with epirubicin at a dose of 50 mgm2and cisplatin at a dose of 60 mgm2administered as a bolus in the hepatic artery on Day 1, combined with systemic continuous infusion of 5FU at a dose of 200 mgm2per day, from Day 1 to Day 14, every 3 weeks.RESULTSTumor sites were the intrahepatic bile ducts in 25 patients and the gallbladder in 5 patients. The overall response rate was 40 12 of 30 patients, including 1 complete response and 11 partial responses. Stable disease was observed in 12 of 30 patients 40 and progressive disease in 6 of 30 patients 20. The median progressionfree and overall survival periods were 7.1 and 13.2 months, respectively, and the 1year and 2year survival rates were 54 and 20, respectively. Performance status improved in 9 of 30 patients 30 and a weight gain of > 7 was observed in 4 of 30 patients 13. The treatment was well tolerated with minimal hematologic toxicity. The major clinical problem was the deep venous thrombosis related to the central venous catheter, which occurred in 5 patients 17.CONCLUSIONSThis novel combined locoregional and systemic chemotherapeutic regimen was found to be active and safe for patients with advanced biliary tract carcinoma. Cancer 2005. © 2005 American Cancer Society. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Plný text