| Autor: |
A, Schwartz M, K, Assoian R |
| Zdroj: |
Journal of Cell Science; July 2001, Vol. 114 Issue: 14 p2553-60, 8p |
| Abstrakt: |
Cell cycle progression in mammalian cells is strictly regulated by both integrin-mediated adhesion to the extracellular matrix and by binding of growth factors to their receptors. This regulation is mediated by G1 phase cyclin-dependent kinases (CDKs), which are downstream of signaling pathways under the integrated control of both integrins and growth factor receptors. Recent advances demonstrate a surprisingly diverse array of integrin-dependent signals that are channeled into the regulation of the G1 phase CDKs. Regulation of cyclin D1 by the ERK pathway may provide a paradigm for understanding how cell adhesion can determine cell cycle progression. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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