| Autor: |
Reichart, Ursula, Kappler, Roland, Scherthan, Harry, Wolf, Eckhard, Mu¨ller, Mathias, Brem, Gottfried, Aigner, Bernhard |
| Zdroj: |
Biochemical and Biophysical Research Communications; March 16, 2000, Vol. 269 Issue: 2 p496-501, 6p |
| Abstrakt: |
Examination of random insertional mutations in transgenic animals harbouring an abnormal phenotype contributes to the discovery of new genes and/or the understanding of already known genes. Here we describe a transgenic mouse line showing early-onset obesity as consequence of the transgene insertion. Molecular genetic analysis revealed a partial deletion of the leptin receptor (Lepr, Ob-R) gene including the coding sequences downstream of exon 17′. This defect prevents the expression of all described membrane-bound isoforms of Ob-R except for isoform Ob-Rc in the homozygous transgenic animals. Thus, this mouse model might be useful for the investigation of the function of the short Ob-R isoforms. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Full Text from ScienceDirect