| Autor: |
Fuss, Babette, Afshari, Fatemah S., Colello, Raymond J., Macklin, Wendy B. |
| Zdroj: |
Molecular and Cellular Neurosciences; August 2001, Vol. 18 Issue: 2 p221-234, 14p |
| Abstrakt: |
In demyelinating diseases, such as multiple sclerosis, an upregulation of MHC class I expression is thought to contribute to oligodendrocyte/myelin damage. In order to investigate potential physiological consequences of upregulated MHC class I expression in oligodendrocytes, we generated transgenic mice that overexpress H-2Ldunder the control of the proteolipid protein (PLP) promoter (PLP-Ldmice). We focused our studies on the MHC class I molecule H-2Ld, because of its unique intracellular transport characteristics. In the CNS of PLP-Ldmice, H-2Ldwas expressed by oligodendrocytes. Furthermore, H-2Ldprotein was transported to and expressed on the surface of oligodendrocytes. Most importantly, this upregulation of MHC class I expression in the CNS of PLP-Ldmice did not by itself result in a de- or dysmyelinating phenotype. These transgenic mice are likely to provide a unique and novel tool for the analysis of potential roles of MHC class I-mediated mechanisms in demyelinating pathologies. |
| Databáze: |
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