| Autor: |
Lapize, Christine, Plüss, Christoph, Werner, Ernst R., Huwiler, Andrea, Pfeilschifter, Josef |
| Zdroj: |
Biochemical and Biophysical Research Communications; October 1998, Vol. 251 Issue: 3 p802-805, 4p |
| Abstrakt: |
GTP cyclohydrolase I is the rate-limiting enzyme in the de novo synthesis pathway of tetrahydrobiopterin which is an essential cofactor for all NO synthase isoforms. The expression of GTP cyclohydrolase I is regulated on a transcriptional level by a variety of cytokines like interleukin 1β or tumor necrosis factor α. The present paper reports that stimulation of protein kinase C by angiotensin II, platelet-derived growth factor BB or the phorbol ester 12-O-tetradecanoylphorbol-13-acetate triggers the phosphorylation and activation of GTP cyclohydrolase I. These data establish that in addition to transcriptional regulation, there is a prominent post-transcriptional modulation of enzyme activity. |
| Databáze: |
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