The Human C/EBPδ (CRP3/CELF) Gene: Structure and Chromosomal Localization

Autor: Cleutjens, C. B.J.M., Eekelen, C. C.E.M. van, Dekken, H. van, Smit, E. M.E., Hagemeuer, A., Wagner, M. J., Wells, D. E., Trapman, J.
Zdroj: Genomics; May 1993, Vol. 16 Issue: 2 p520-523, 4p
Abstrakt: In an attempt to identify C/EBP-like transcription factors expressed in the prostate, a cDNA homologous to the mouse C/EBPδ (CRP3) and the rat CELF gene was isolated. A genomic clone containing the entire C/EBPδ gene was isolated using a cDNA fragment as a probe. The gene was characterized by restriction mapping and sequence analysis. By fluorescence in situ hybridization, using tile biotinylated genomic clone as a probe, the C/EBPδ gene was assigned to the pericentromeric region of human chromosome 8, most probably to 8q11. This chromosomal localization was confirmed by analysis of a panel of human x hamster somatic cell hybrid DNA samples with a C/EBPδ-specific STS. As a result, the C/EBPδ gene could be positioned between the PLAT and the MOS loci. Copyright 1993, 1999 Academic Press
Databáze: Supplemental Index