| Autor: |
Liu, Qirui, Yin, Yaxin, Fan, Shuo, Qiu, Wenpei, Pan, Daodong, Du, Ming, Zheng, Xiaojiao, Tu, Maolin |
| Zdroj: |
Food Bioscience; 20240101, Issue: Preprints |
| Abstrakt: |
The necessity for natural antioxidants, coupled with the high prevalence of colitis and the challenges associated with its treatment, has garnered significant attention. This study aims to investigate the antioxidant activity of whey protein (WP) peptides and their roles and mechanisms in dextran sulfate sodium (DSS)-induced colitis in mice by hydrolysis of WP with neutral protease. The results showed that the WP-derived peptides had remarkable free radical scavenging and metal ion chelating capabilities. The symptoms of DSS-induced colitis in mice were effectively ameliorated, primarily through the regulation of mRNA expression of inflammatory cytokines, enhancement of tight junctions and and modification of the level of oxidative stress. Furthermore, the administration of WP peptides resulted in an increase in the relative abundance of beneficial bacteria within the intestinal tract of mice with enteritis, accompanied by a significant inhibition of the growth of harmful bacteria. This led to an improvement in the intestinal microecological environment, which in turn led to a further alleviation of colitis symptoms. These results serve to establish a foundation for further investigation into the efficacy of antioxidant peptides, and provide a scientific basis for the development of colitis prevention strategies based on the WP, which demonstrate a broad range of potential applications. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Full Text from ScienceDirect