| Autor: |
Nassir, Molhm, Gherardi, Luca, Redman, Richard L., Jin, Yonghao, Yao, Feng, Yang, Yang, Raheja, Nicholas, Natarajan, Arjun, Butler, David, Knouse, Kyle W., Baran, Phil S. |
| Zdroj: |
Organic Letters; 20240101, Issue: Preprints |
| Abstrakt: |
Three critical advances in simplifying the adoption of P(V)-based stereopure, phosphorothioate-containing oligonucleotide synthesis are reported. A more inexpensive phosphorus–sulfur incorporation reagent (ΨBr) is introduced, a robust linker system was developed, and a systematic study of common nucleobase protecting groups was performed to significantly reduce the barrier to adoption of this technology. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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