Effect of induction therapy with mycophenolate or cyclophosphamide on serum BAFF levels in patients with systemic lupus erythematosus

Autor: Herrera, Alejandra Betancur, Restrepo, Juan José Mariño, Restrepo, Tulio Lopera, Montoya, Laura Robledo, Restrepo, Juan Felipe Soto, García, Adriana Lucía Vanegas, Vahos, Carlos Horacio Muñoz, Coronado, Juan Camilo Díaz, Tamayo, Ricardo Antonio Pineda, Vásquez, Gloria
Zdroj: Revista Colombiana de Reumatología (English Edition); 20240101, Issue: Preprints
Abstrakt: Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which B cell hyperactivity plays a key role in its pathophysiology. In this disease, the B cell activating factor (BAFF) is implicated in the loss of immunological tolerance, and high concentrations of this factor have been linked to disease progression. It is unknown how induction therapies with cyclophosphamide (CFM) or mycophenolate (MMF) modulate BAFF levels.
Databáze: Supplemental Index