| Autor: |
Boudia, Fabien, Baille, Marie, Babin, Loélia, Aid, Zakia, Robert, Elie, Rivière, Julie, Galant, Klaudia, Perez, Veronica Alonso, Anselmi, Laura, Arkoun, Brahim, Abermil, Nassera, Marzac, Christophe, Bertuccio, Salvatore Nicola, Regnault de Premesnil, Alexia, Lopez, Cécile K., Eeckhoutte, Alexandre, Naimo, Audrey, Leite, Betty, Catelain, Cyril, Metereau, Christophe, Gonin, Patrick, Gaspar, Nathalie, Schwaller, Jürg, Bernard, Olivier A., Raslova, Hana, Gaudry, Murielle, Marchais, Antonin, Lapillonne, Hélène, Petit, Arnaud, Pflumio, Françoise, Arcangeli, Marie-Laure, Brunet, Erika, Mercher, Thomas |
| Zdroj: |
Blood; 20240101, Issue: Preprints |
| Abstrakt: |
•Precise engineering of the ETO2::GLIS2 fusion in iPSC reproduces leukemogenesis in a developmentally relevant human cell context.•The temporal orchestration of chromatin changes by ETO2::GLIS2 reveals hijacking of the osteoblastic homeobox DLX3 factor.•DLX3 contributes to imbalanced activities at ETS and GATA motifs and is essential for ETO2:GLIS2 leukemia initiation from iPSC. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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