| Autor: |
Czeskis, Boris A., O'Bannon, Douglas D., Wheeler, William J., Clodfelter, Dean K. |
| Zdroj: |
Journal of Labelled Compounds and Radiopharmaceuticals; February 2005, Vol. 48 Issue: 2 p85-100, 16p |
| Abstrakt: |
Asymmetric synthesis of AMPA potentiator LY450108‐[14C] containing 14C‐label attached to the chiral center of the molecule, was accomplished based on Evans' chiral oxazolidinone auxiliary method. Diastereoselective methylation of p‐nitrophenylacetic acid derivative was used as a key step. The auxiliary was reductively removed, and the resulting primary alcohol was converted into the corresponding amine. Its sulfonylation, reduction of the aromatic nitro group, and acylation with 3,5‐difluorobenzoyl chloride led to the final product. The synthesis of tritiated LY450108 is also detailed. Copyright © 2005 John Wiley & Sons, Ltd. |
| Databáze: |
Supplemental Index |
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