| Autor: |
Soumya, Sasikumar Jalajakumari, Abhinand, Chandran Sheela, Nair, Arya Saseendran, Sonu, Priji Sathyan, Mohanadasan Nair, Govindapillai, Gangaprasad, Appukuttan Nair, Nair, Achuthsankar S., Nair, Ananthakrishnan Jayakumaran |
| Zdroj: |
Journal of Biomolecular Structure and Dynamics; December 2024, Vol. 42 Issue: 21 p11425-11434, 10p |
| Abstrakt: |
AbstractAdipose tissue is the major storage site of lipids and plays a vital role in energy homeostasis. Adipogenesis is a well-regulated process wherein preadipocytes differentiate into adipocytes. It requires the sequential activation of numerous transcription factors, including peroxisome proliferator activated receptor-γ (PPAR-γ). Phytochemicals have been reported to regulate adipogenesis and flavonoids represent the most researched groups of phytochemicals with regard to their effect on adipogenesis. Chrysin is a naturally occurring flavone and is reported to have anti-inflammatory effects in obese conditions. The present study was aimed to examine the effect of chrysin on adipogenesis. In silicoMolecular docking, dynamic simulation studies and in vitrocell-based assays showed that chrysin inhibited adipogenesis by modulating key adipogenic transcription factor PPARγ. Enhanced adipogenesis leads to obesity and targeting adipogenesis is potential in regulating adipose tissue development. So, these investigations may provide important information for designing therapeutic interventions to control adiposity.Communicated by Ramaswamy H. Sarma |
| Databáze: |
Supplemental Index |
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