A cluster randomized trial of xylitol chewing gum for prevention of preterm birth: The PPaX trial

Autor: Valentine, Gregory C., Antony, Kathleen M., Sangi-Haghpeykar, Haleh, Wood, Alexis C., Chirwa, Rose, Petro, Saukani, Dumba, Mary, Nanthuru, Deborah, Shope, Cynthia, Mlotha-Namarika, Jesse, Wilkinson, Jeffrey, Aagaard, Joshua, Aagaard, Ellen J., Seferovic, Maxim D., Levison, Judy, Kazembe, Peter, Aagaard, Kjersti M.
Zdroj: Med; 20240101, Issue: Preprints
Abstrakt: Maternal periodontal disease is associated with preterm and low-birthweight deliveries, but randomized trials of likely efficacious treatments (e.g., dental scaling and root planing) during pregnancy have not reduced these adverse outcomes. As an alternative, we hypothesized that periconception initiation of xylitol chewing gum would reduce the occurrence of preterm or low-birthweight deliveries among a historical high-prevalence population in Malawi.
Databáze: Supplemental Index