| Autor: |
Sahaya, Hilna Diana, Ardiansah, Bayu, Hudiyono, Sumi, Prabandari, Erwahyuni Endang, Ariyani, Titin, Wukirsari, Tuti, Tanimoto, Hiroki, Cahyana, Antonius Herry |
| Zdroj: |
Case Studies in Chemical and Environmental Engineering; December 2024, Vol. 10 Issue: 1 |
| Abstrakt: |
Herein, oleic acid was derivatized to 1,2,3-triazolyl oleate esters through propargylation followed by copper(I)-mediated azide-alkyne [3 + 2] cycloaddition, confirmed by IR, NMR and HRMS. All products exhibited similar antioxidant activity to oleic acid. The products demonstrated antibacterial activity at 10 mg/mL. Compound 4dwas identified as the most potent cytotoxic agent, showing 34.31 % inhibition at 200 μM against the MCF-7. Additionally, 4ddisplayed 15.85 % inhibition of shikimate kinase at 0.5 mg/mL. Thus, these modified compounds exhibit better activity compared to oleic acid, making this series a promising candidate for drug discovery and development. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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