| Autor: |
Irfan, Muhammad, Nasir, Tahira, Ahmad, Muhammad Jawwad, Lau, Woei Jye, Irfan, Masooma, Zia, Muhammad Khaqan, Akram, Muhammad, Kanwal, Qudsia, Ullah, Hidayat, Yaqub, Mustansara |
| Zdroj: |
Emergent Materials; 20240101, Issue: Preprints p1-15, 15p |
| Abstrakt: |
N-3-(triethoxysilyl)propylamine (APTES)-grafted mesoporous silica (MCM41) based materials were used in different biomedical applications like tissue engineering, bone scaffold and cancer studies, but they were never evaluated in blood dialysis. In this work, mesoporous inorganic–organic hybrid materials, formed by grafting APTES onto MCM-41 (APTES-g-MCM41), were prepared and incorporated into polyurethane (PU) as fillers for the fabrication of dialysis membranes. A comprehensive study of fabricated membranes was performed that covered various physical and chemical properties like surface morphology, hydrophilicity, porosity, surface roughness, blood clotting and dialysis performances. Successful synthesis of APTES-g-MCM41 was confirmed by Fourier transform Infrared spectroscopy (FTIR), whereas scanning electron microscopy (SEM) analysis showed that higher amount of filler addition (10%) to PU membrane matrix could lead to improved porosity and hydrophilicity. Atomic force microscopy (AFM) provided the surface roughness data and water absorbance measurements explained the hydrophilic/hydrophobic behavior. The results indicated that increasing the loading of APTES-g-MCM41 into the PU matrix led to reduced protein adsorption, enhanced thrombin time, prothrombin time and plasma recalcification time, suggesting improved anticoagulant properties. Additionally, a 2–4% red blood cell destruction (hemolysis) was observed. The clearance rates of 57.6% and 55.2% for creatinine and urea, respectively were obtained via the dialysis experiments using dialysis cell. The overall results indicated that some of the fabricated membranes have potential for scale-up studies. However, detailed cytotoxicity testing on animal and human models, along with antibacterial analysis, is required for further evaluation. |
| Databáze: |
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