| Autor: |
Abdulkader, Regina C, Silva, Helio B, Marcondes, Marcello, Vasconcelos, Eleonidas A, Paiva, Antonio C M |
| Zdroj: |
Journal of Pharmacy and Pharmacology; September 1979, Vol. 31 Issue: 1 p20-22, 3p |
| Abstrakt: |
Depot administration of a lipophilic angiotensin II (AII) antagonist was tested for obtaining prolonged inhibition of the pressor response to AII in rats. Intramuscular injections of 1.5 or 5.0 mg of octanoyl-[Leu8]AII (oct-LAII), in oil solution produced the same degree of AII inhibition either 6 h or 24 h after the injection. The inhibition was comparable to that expected from the continuous intravenous infusion of oct-LAII at the rate of 1.2 μg kg−1min−1. The prolonged effect of intramuscular injections of oct-LAII in oil solution may be useful for chronic studies of physiopathological states involving the renin-angiotensin-aldosterone system. |
| Databáze: |
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