Analgesic and Antipyretic Properties of Some Aspirin Derivatives

Autor: Weaver, L C, Richards, Alice B, Martin, H E
Zdroj: Journal of Pharmacy and Pharmacology; September 1961, Vol. 13 Issue: 1 p105-110, 6p
Abstrakt: Several derivatives of acetylsalicylic acid have been tested for analgesic and antipyretic properties in mice and rats. o-Diphenylacetoxy benzoic acid (O-(diphenylacetyl)salicylic acid; DPA) is a superior analgesic but an inferior antipyretic to aspirin, DPA has a low toxicity: it failed to show significant anti-inflammatory or tranquillising properties. In dogs it produced only slight and transient falls in blood pressure and there was no appreciable effect on the direct or reflex muscle preparation.
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