| Autor: |
CRESSMAN, W A, SUGITA, E T, DOLUISIO, J T, NIEBERGALL, P J |
| Zdroj: |
Journal of Pharmacy and Pharmacology; December 1966, Vol. 18 Issue: 12 p801-808, 8p |
| Abstrakt: |
A kinetic method was developed to study the interactions between cupric ion and penicillins G and V. Complexation was found to occur with the intact penicillins, followed by rapid hydrolysis of the complex into the corresponding penicilloic acid-cupric ion complex. The logarithmic stability constants for the interaction between cupric ion and penicillins G and V were found to be 2·61 and 2·24, respectively. In addition, the method of continuous variation was used to determine the logarithmic stability constants for the cupric ion-penicilloic acid complexes. These were found to be 4·20 and 4·50, for penicilloic V and G acids respectively. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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