| Autor: |
Lavender, Marjorie K, Parkes, M W |
| Zdroj: |
Journal of Pharmacy and Pharmacology; April 1973, Vol. 25 Issue: 4 p297-301, 5p |
| Abstrakt: |
A method is described for the assessment of the protective activity of drugs against the lethal effect of intravenously infused ouabain in mice. Electrocardiographic studies confirmed that protection is exerted against a cardiotoxic action of the glycoside. Activities are quoted for some β-adrenoceptor blocking agents. Both (-)- and (+)-enantiomers of propranolol were active but only the (-)-enantiomer of sotalol and INPEA-drugs devoid of membrane-stabilizing properties. |
| Databáze: |
Supplemental Index |
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