Adsorption of benzoic acid on sulphadimidine: suppressive effect of some hydrophilic polymers

Autor: Khalil, Saleh A H, Nasipuri, R N
Zdroj: Journal of Pharmacy and Pharmacology; February 1973, Vol. 25 Issue: 2 p138-142, 5p
Abstrakt: The uptake of benzoic acid on sulphadimidine particles has been investigated. Depending on the concentration of sulphadimidine in the system, benzoic acid was adsorbed to the extent of 94%. Data from the adsorption experiments were shown to fit a Langmuir plot for systems containing up to 0.2 g 100 ml−1sulphadimidine. The suppressive effect of three hydrophilic polymers on adsorption was studied; the results followed the sequence: Polyvinylpyrrolidone (PVP) > methylcellulose > sodium carboxymethylcellulose. Dialysis experiments revealed that, within the range of concentrations used, neither PVP nor methylcellulose was significantly bound to benzoic acid.
Databáze: Supplemental Index