| Autor: |
Baillie, A J, Coombs, G H, Dolan, T F, Hunter, C A, Laakso, T, Sjöholm, I, Stjärnkvist, P |
| Zdroj: |
Journal of Pharmacy and Pharmacology; October 1987, Vol. 39 Issue: 10 p832-835, 4p |
| Abstrakt: |
Liver parasite burdens of Leishmania donovaniin the mouse have been determined after treatment with intravenous administration of sodium stibogluconate in the free or carrier form. The carrier form, in which the drug was covalently bound to polyacryl starch microparticles, was up to 100 x more effective than the free form in this murine model of visceral leishmaniasis. Empty microparticles had no effect on liver parasite burdens and the enhanced in-vivo antileishmanial activity of the carrier form of the drug was apparently due to passive drug delivery to the infected liver. |
| Databáze: |
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