| Autor: |
Hori, Ryohei, Okano, Tomonobu, Kato, Miyako, Maegawa, Hitoshi, Inui, Ken-Ichi |
| Zdroj: |
Journal of Pharmacy and Pharmacology; September 1988, Vol. 40 Issue: 9 p646-647, 2p |
| Abstrakt: |
The absorption of seven cephalosporin antibiotics from the in-situ intestinal loop at pH 7.4 and their transport by brush-border membrane vesicles in the presence of an inward H+gradient ([pH]i= 7.5, [pH]o= 6.0) were examined. A good correlation was found between the intestinal absorption rate and the initial uptake rate by brush-border membrane vesicles. The data suggest that the transport study using intestinal brush-border membrane vesicles is useful as a model system for the intestinal absorption of β-lactam antibiotics. |
| Databáze: |
Supplemental Index |
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