| Autor: |
Yates, M S, Askey, Elizabeth A, Wilmot, Susan E, Bowmer, C J |
| Zdroj: |
Journal of Pharmacy and Pharmacology; January 1986, Vol. 38 Issue: 1 p59-62, 4p |
| Abstrakt: |
Cardiac chronotropic responses to isoprenaline, carbachol and electrical stimulation of the cervical sympathetic and vagal nerves were recorded in rats with glycerol-induced acute renal failure (ARF) and control rats. The experiments involving electrical stimulation of cardiac nerves were performed in rats which either had been pretreated with indomethacin (1 mg kg−1twice daily for 2 days) or had undergone acute bilateral renal pedicle ligation. The findings from this investigation indicate that the reduced chronotropic responses to vagal stimulation in rats with glycerol-induced ARF are due to a reduction in acetylcholine release mediated by prostaglandins possibly originating from the damaged kidneys. The diminished response to cervical sympathetic stimulation results from a decreased postsynaptic response to β-adrenoceptor stimulation. |
| Databáze: |
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