| Autor: |
Yamada, Shigeto, Yokoo, Hideyasu, Nishi, Syogoro |
| Zdroj: |
Journal of Pharmacy and Pharmacology; May 1993, Vol. 45 Issue: 5 p479-481, 3p |
| Abstrakt: |
(–)-Sulpiride (10 Nm-10 μm) in the superfusate, dose-dependently increased the electrically-evoked release of dopamine from rat striatal slices. (+)-Sulpiride had little effect on evoked release of dopamine up to 10 μm. Apomorphine inhibited electrically evoked release of dopamine, and this effect of apomorphine was antagonized by (–)-sulpiride. SCH23390 and forskolin had no effect on the (–)-sulpiride-induced increase in evoked release of dopamine. Treatment with the irreversible dopamine-receptor antagonist N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline caused a significant increase in evoked release of dopamine and prevented the (–)-sulpiride-induced increase in the evoked release of dopamine. These results indicate that the (–)-sulpiride-induced increase in evoked release of dopamine is due to antagonism of the activation of dopamine autoreceptors by endogenously released dopamine. |
| Databáze: |
Supplemental Index |
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