A Novel Protocol Improves Engraftment in Tαβ +Cell Depleted Haplo-HSCT for Patients with Thalassemia Major

Autor: Liao, Jianyun, Bu, Chaoke, He, Lan, He, Yuelin, He, Jujian, Chen, Dan, Lyu, Bo, Zhang, Weiwei, Tang, Haoran, Liu, Xinrui, Li, Chunfu
Zdroj: Blood; November 2023, Vol. 142 Issue: 1, Number 1 Supplement 1 p4953-4953, 1p
Abstrakt: Background:Hematopoietic stem cell transplantation (HSCT) remains a proven curative approach for patients with thalassemia major (TM) over long-term practice. However, achieving successful engraftment and managing graft-versus-host disease (GVHD) continue to pose significant challenges. While low incidence of GVHD has been observed in Tαβ +cell-depleted HSCT (TDH) from haploidentical donors, graft failure (GF) remains a considerable concern, particularly in patients with TM. To enhance the engraftment in TM-TDH, we conducted this prospective/retrospective single-center clinical study.
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